FREUND-VECTOR VFC-LAB 3 FLO-COATER - INCLUDES Granuex GXR-35 Conical Rotor & HOT MELT System - INSERTS
A portable lab scale fluid bed with drying, top spray, and bottom spray
Attachment to the VFC-3 to allow for the granulation of binders in a molten state
Attachment to the VFC-3 to allow for the creation of spheres and drug layering
VFC-LAB 3 FLO-COATER® OEM DETAILS:
With its standard drying, top spray and bottom spray capabilities, as well as the optional GRANUREX® rotor insert, the VFC-LAB FLO-COATER® series are the most versatile laboratory scale fluid bed systems available.
The unique design of the combination product container/Wurster processing insert and integrated solution pump eliminates the need for costly “add-ons”. The combination product container also allows for quick changeover and cleaning between processes.
Portable, flexible, efficiently cleaned, and easy to operate, the VFC-LAB series is the perfect solution for your process development requirements.
Multi-Purpose Laboratory Fluid Bed Systems
One System – Four Processes
Top Spray Granulation Processes
Bottom Spray Coating Processes
Patented Wurster Accelerator System for Reduced Process Time
Drying Processes
Granurex® Rotor Technology (patented) *
Spherical Coating and Layering Processes
Portable Self-Contained System
Electrical and Compressed Air Connections for Easy Removal of System
Quick Changeover Design
No Tools Required for Process Changeover
Removable Spray Gun and Product Screens
Removable Cartridge Filters (2 micron retention)
TECHNICAL SPECIFICATIONS:
Capacity (Top Spray): 10 L
Capacity (Dryer): 12 L (Standard)
Capacity (Dryer): 20 L (Optional Insert)
Capacity (Wurster): 9 L (8 Inch)
Capacity (GRANUREX® GXR): 10 L
Inlet Air Temperature: 100°C (maximum)
Process Air Volume: 280 m³/hr
Compressed Air Supply: 50 m³/hr @ 6 bar
Electrical Supply: 220/400 VAC, 50 – 60 Hz, 3 Phase
Weight: 630 kg (approximate)
Solution Delivery Rate: 1.25 – 110 mL/min
Design Standards: CE, ATEX, UL, NFPA, CSA. VDI 2263
Solvent Rating: Non-hazardous
GRANUEX GXR-35 CONICAL ROTOR - OEM DETAILS:
GRANUREX® is the most powerful pellet/powder processor available in the market place. The applications are endless:
1. Pellet Formation: Spherical granulation of powders into spherical granules/pellets (as low as 50 micron).
2. Solution/Suspension Coating: Precisely applying a coating onto a core material
3. Dry Powder Layering: Rapidly increasing size of pellet by directly applying a powder. The powder could be an API (Active Pharmaceutical Ingredient), a controlled release polymer, or an excipient.
Finely divided/Micronized API and excipient is loaded on to a conical rotor. Air atomized binder liquid is applied to the powder. Rotor energy is used to densify and spheronize the powder resulting in uniform granules.
Applying solution or suspension based active or polymer via air atomizing spray gun. The process may include application of glidant or other excipient via the precision powder feeder to enhance the rate of spray and/or the amount of solids applied per unit time. Some actives and polymers are adhesive as they dry, applying glidant via the powder feeder can improve spray rates dramatically by mitigating this adhesive nature. In some cases this can allow solid content in solution/suspension to be doubled. Conventionally, glidant may be added to the suspension before spraying. By not adding it to the suspension, gun blockage is eliminated, suspension preparation is simple and the process is streamlined.
A powder feed system can be integrated into the GRANUREX® process, which greatly increases the rate of pellet formation. Finely divided/Micronized API and/or micronized polymer and/or micronized excipient is loaded in to a precision powder feeder. Core particles from 100 to 2000+ microns are loaded on to a conical rotor. A small amount of binder, plasticizer or liquid solvent is atomized and sprayed on to the core particles while the dry micronized powders are fed in to the cores via the precision powder feeder. Rotor energy and the precise balance of micronized powder and liquid addition results in very fast coatings of active, polymer or combinations that would take hours or days if applied conventionally from solution. Product movement on the rotor ensures very high uniformity.
Historically, rotor-based processors were limited on drying capacity.
FREUND designed the Drying Accelerator Duct within the GRANUREX® processor.
This greatly reduces process time and increases yield.
In this picture, the spherical granulation process is complete and the product is getting dried via the Drying Accelerator Duct.
